منابع مشابه
Differential TAM receptor–ligand–phospholipid interactions delimit differential TAM bioactivities
The TAM receptor tyrosine kinases Tyro3, Axl, and Mer regulate key features of cellular physiology, yet the differential activities of the TAM ligands Gas6 and Protein S are poorly understood. We have used biochemical and genetic analyses to delineate the rules for TAM receptor-ligand engagement and find that the TAMs segregate into two groups based on ligand specificity, regulation by phosphat...
متن کاملTam 194-201.qxd
194 JADA, Vol. 135, February 2004 R E S E A R C H Background. Light-activated bleaching is a method of tooth whitening. The authors conducted a study to compare the whitening effects and tooth temperature changes induced by various combinations of peroxide bleaches and light sources. Methods. The authors randomly assigned 250 extracted human teeth halves into experimental groups (n = 10). A pla...
متن کاملQuo vadis TAM?
The Technology Acceptance model (TAM) is one of the most influential theories in Information Systems. However, despite the model's significant contributions, the intense focus on TAM has diverted researchers’ attention away from other important research issues and has created an illusion of progress in knowledge accumulation. Furthermore, the independent attempts by several researchers to expan...
متن کاملTAM receptor signalling and demyelination.
The TAM family (Tyro3, Axl and Mer) of receptor protein tyrosine kinases play pivotal roles in a number of major cellular processes: cell survival and proliferation, immunomodulation and phagocytosis. These processes are central to both the initial development and pathological course of human multiple sclerosis. All three receptors and their ligands, Gas6 (growth arrest-specific gene 6) and pro...
متن کاملDiversification of TAM receptor function
Apoptotic cell clearance is critical for both tissue homeostasis and the resolution of inflammation. We found that the TAM receptor tyrosine kinases Axl and Mer played distinct roles as phagocytic receptors in these two settings, where they exhibited divergent expression, regulation, and activity. Mer acted as a tolerogenic receptor in resting macrophages and in settings of immune suppression. ...
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ژورنال
عنوان ژورنال: Revista Iberoamericana
سال: 1942
ISSN: 2154-4794,0034-9631
DOI: 10.5195/reviberoamer.1942.1177